|hepcisovoku||Дата: Четверг, 13 Август 2015, 18:14 | Сообщение # 1|
|How do the new drugs – generic Sovaldi (Sofosbuvir) and Simeprevir (Olysio) function in the human body? |
These two drugs – what are known as direct-acting agents—one of them, Simeprevir, is a protease inhibitor. It suppresses protease so the virus can’t multiply. It suppresses the multiplication of Hepatitis C virus. There are other efficient drugs occupying the main niche in the sphere. Additionally to Simeprevir, we have generic Sovaldi (Sofosbuvir), which may be even more effective than Simeprevir as the researches demonstrate. For generic Sovaldi (Sofosbuvir), the mechanism of action is known as a polymerase inhibitor. Both drugs are direct-acting agents and influence directly the virus and its properties. There has also been initiated a Phase 3 clinical trial to investigate the effectiveness of this peculiar combination of these two drugs in adult HCV genotype 1 patients with developed advanced fibrosis and null responders who suffer from any stage of fibrosis.
What makes them actually so irreplaceable is the evident high cure rate! It’s the high cure rate and much shortened length of treatment. In order to see what we’re doing now, we need to look into the future. So, we have the potent drugs that can kill Hepatitis C without the usage of Interferon or Ribavirin, which demonstrate cure rates of 95 percent plus.
Some of the future treatments courses will not depend on genotype. Treatment will be one pill one pill a day for quick Hepatitis C elimination. It won’t be just a treatment but a final perspective of cure. If you glance back into the past, there was registered a 50 percent cure rate if patients suffered from Hepatitis C alone—not taken HIV and Hepatitis C into account. The total cure rate for that made up 20 percent.
Already in 2011, treatment looked more effective with direct-acting agents. Generic Sovaldi (Sofosbuvir), usede initially with Peginterferon and Ribavirin turn out to have an 80 percent plus cure rate in genotype 1. Genotype 2 doesn’t imply Interferon; you will be taking generic Sovaldi (Sofosbuvir) and Ribavirin within12 weeks and you’re cured. <There>are indications of rash and pain caused.
Cure rates reach approximately 94 percent for people not undergoing treatment in the past. Cure rates are shown to be lower for individuals with severe liver disease or patients who have undergone treatment in the past. If you observe genotype 1 patients category, it’s 80 percent plus.
It is a pleasure to watch people, who take these drugs, are recovering. Many people say that they feel better than they have in years; a few are complaining of some side effects. Photosensitivity seems to be the biggest disturbance. But it can be overcome. It cannot be compared with previous terrible adverse reactions.
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